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Crystal structure of SLX1-SLX4

Analyse Crystal structure of SLX1-SLX4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7CQ3
Type: protein
Length: 372 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Structure-specific endonuclease subunit SLX1; SLX4 isoform 1
EC: 3.1.-.-
UniProt: A6ZLG6, A0A6A5PU22
Ligands: ZN, SO4
Pockets: 6 · best druggability 0.52

Structure

x-ray diffraction · 2 distinct chains · 48% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Structure-specific endonuclease subunit SLX1 (EC 3.1.-.-)	protein	298	43% helix, 17% strand	A6ZLG6
B	SLX4 isoform 1	protein	74	68% helix, 5% strand	A0A6A5PU22

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A
SO4 · Sulfate ion · ion · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	197	0.52	0.78	26	empty
2	171	0.46	0.76	31	empty
3	97	0.42	0.78	20	empty
4	89	0.40	0.77	19	empty
5	61	0.32	0.76	16	empty

Interfaces

1 interface between chains.

A–B · 1059 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

7CQ3 · Crystal structure of Slx1-Slx4 · the same entry in another collection · chain A against A, TM-score 1.00
A6ZLG6 · AlphaFold monomer V2.0 prediction for structure-specific endonuclease subunit SLX1… · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A6ZLG6
Every structure of UniProt A0A6A5PU22
Elsewhere: RCSB PDB 7CQ3 · PDBe 7CQ3 · UniProt A6ZLG6 · UniProt A0A6A5PU22

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