Research workbench
The endonuclease domain of colicin E7 in complex with its inhibitor IM7 protein
Analyse The endonuclease domain of colicin E7 in complex with its inhibitor IM7 protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7CEI
- Type
- protein
- Length
- 214 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (colicin E7 immunity protein)
- UniProt
- Q03708, Q47112
- Ligands
- ZN
- Pockets
- 5 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (colicin E7 immunity protein) | protein | 87 | 51% helix, 0% strand | Q03708 |
| B | Protein (colicin E7 immunity protein) | protein | 127 | 31% helix, 15% strand | Q47112 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 89 | 0.42 | 0.79 | 15 | empty |
| 2 | 107 | 0.40 | 0.76 | 27 | empty |
| 3 | 67 | 0.38 | 0.79 | 17 | empty |
| 4 | 96 | 0.33 | 0.73 | 18 | empty |
| 5 | 65 | 0.30 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 759 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 7CEI · The endonuclease domain of colicin E7 in complex with its inhibitor IM7 protein · the same entry in another collection · chain A against A, TM-score 1.00
- Q03708 · AlphaFold monomer V2.0 prediction for colicin-E7 immunity protein (Q03708) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q47112 · AlphaFold monomer V2.0 prediction for colicin-E7 (Q47112) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03708
- Every structure of UniProt Q47112
- Elsewhere: RCSB PDB 7CEI · PDBe 7CEI · UniProt Q03708 · UniProt Q47112
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