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Crystal structure of 2019-ncov nucleocapsid C-terminal domain (ctd) protein

Analyse Crystal structure of 2019-ncov nucleocapsid C-terminal domain (ctd) protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7CE0
Type: protein
Length: 440 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoprotein
UniProt: P0DTC9
Pockets: 4 · best druggability 0.48

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Nucleoprotein	protein	110	40% helix, 18% strand	P0DTC9

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	259	0.48	0.73	32	empty
2	101	0.40	0.77	16	empty
3	73	0.33	0.75	15	empty
4	54	0.27	0.74	16	empty

Interfaces

3 interfaces between chains.

B–C · 2669 Å² buried · 42 hydrogen bonds · protein-protein
A–D · 2652 Å² buried · 41 hydrogen bonds · protein-protein
A–B · 219 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

7CE0 · Crystal structure of 2019-nCoV nucleocapsid C-terminal domain (CTD) protein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0DTC9
Elsewhere: RCSB PDB 7CE0 · PDBe 7CE0 · UniProt P0DTC9

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