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Crystal structure of an integral membrane steroid 5-alpha-reductase PBSRD5A

Analyse Crystal structure of an integral membrane steroid 5-alpha-reductase PBSRD5A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7C83
Type: protein
Length: 251 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3-oxo-5-alpha-steroid 4-dehydrogenase
UniProt: A0A3A0FWV3
Ligands: NDP
Pockets: 1 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 69% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3-oxo-5-alpha-steroid 4-dehydrogenase	protein	251	69% helix, 3% strand	A0A3A0FWV3

Ligands and binding sites

NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 8 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	676	0.86	0.90	64	NDP, OLC

Compared structures

7C83 · Crystal structure of an integral membrane steroid 5-alpha-reductase PbSRD5A · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A3A0FWV3
Elsewhere: RCSB PDB 7C83 · PDBe 7C83 · UniProt A0A3A0FWV3

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