Crystal structure of glycyrrhiza uralensis UGT73P12 complexed with glycyrrhetinic acid 3-O-monoglucuronide

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 14% strand (DSSP).

Ligands and binding sites

• UDP · Uridine-5'-diphosphate · ligand · chains A
• FJL · (2~{S},3~{S},4~{S},5~{R},6~{R})-6-[[(3~{S},4~{A}~{R}, 6~{A}~{R},6~{B}~{S},8~{A}~{S},11~{S},12~{A}~{R}, 14~{A}~{R},14~{B}~{S})-11-carboxy-4,4,6~{A},6~{B}, 8~{A},11,14~{B}-heptamethyl-14-oxidanylidene-2,3, 4~{A},5,6,7,8,9,10,12,12~{A},14~{A}-dodecahydro-1~{H}-picen-3-yl]oxy]-3,4,5-tris(oxidanyl)oxane-2-carboxylic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 7C2X · Crystal Structure of Glycyrrhiza uralensis UGT73P12 complexed with glycyrrhetinic acid… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt A0A5A4WN00
• Elsewhere: RCSB PDB 7C2X · PDBe 7C2X · UniProt A0A5A4WN00