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Crystal structure of POLARISACT(T57S), genetically encoded probe for fluorescent polarization

Analyse Crystal structure of POLARISACT(T57S), genetically encoded probe for… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7C03
Type: protein
Length: 312 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: POLARISACT(T57S)
Ligands: GYS
Pockets: 3 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	POLARISACT(T57S)	protein	312	16% helix, 46% strand	—

Ligands and binding sites

GYS · [(4Z)-2-(1-amino-2-hydroxyethyl)-4-(4-hydroxybenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]acetic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	96	0.77	0.97	25	GYS
2	235	0.53	0.76	30	empty
3	161	0.43	0.75	27	empty

Modifications

Observed in the structure: 2 cofactor (chromophore).

Compared structures

7C03 · Crystal structure of POLArISact(T57S), genetically encoded probe for fluorescent… · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7C03 · PDBe 7C03

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