Research workbench
Clathrin heavy chain N-terminal domain complexed with peptide from protein mu-ns of reovirus type 1
Analyse Clathrin heavy chain N-terminal domain complexed with peptide from protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BN1
- Type
- protein
- Length
- 738 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Clathrin heavy chain 1; Protein mu-ns from reovirus type 1
- UniProt
- Q00610
- Pockets
- 5 · best druggability 0.83
Structure
x-ray diffraction · 4 distinct chains · 9% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Clathrin heavy chain 1 | protein | 361 | 9% helix, 51% strand | Q00610 |
| B | Clathrin heavy chain 1 | protein | 360 | 9% helix, 51% strand | Q00610 |
| E | Protein mu-ns from reovirus type 1 | protein | 8 | 0% helix, 13% strand | — |
| F | Protein mu-ns from reovirus type 1 | protein | 9 | 0% helix, 11% strand | — |
Ligands and binding sites
- PG4 · Tetraethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1138 | 0.83 | 0.84 | 117 | empty |
| 2 | 687 | 0.75 | 0.80 | 73 | empty |
| 3 | 72 | 0.33 | 0.76 | 17 | empty |
| 4 | 61 | 0.32 | 0.76 | 17 | empty |
| 5 | 53 | 0.25 | 0.73 | 17 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1035 Ų buried · 14 hydrogen bonds · protein-protein
- B–F · 533 Ų buried · 4 hydrogen bonds · protein-protein
- A–E · 509 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7BN1 · Clathrin heavy chain N-terminal domain complexed with peptide from Protein mu-NS of… · the same entry in another collection · chain A against A, TM-score 1.00
- Q00610 · AlphaFold monomer V2.0 prediction for clathrin heavy chain 1 (Q00610) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00610
- Elsewhere: RCSB PDB 7BN1 · PDBe 7BN1 · UniProt Q00610
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