UniProt Q00610
Clathrin heavy chain 1 (Q00610)
Clathrin heavy chain 1 (UniProt Q00610): 16 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 63 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q00610
- Protein
- Clathrin heavy chain 1
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 63 · 12 records with a druggable one
Structures
17 records of Q00610 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2XZG | Clathrin Terminal Domain Complexed with Pitstop 1 | x-ray diffraction | A | VH1 | 3 (best 0.76) |
| 2XZG | Clathrin terminal domain complexed with pitstop 1 | x-ray diffraction | A | VH1 | 3 (best 0.76) |
| 4G55 | Clathrin terminal domain complexed with pitstop 2 | x-ray diffraction | A | VH2 | 5 (best 0.77) |
| 4G55 | Clathrin terminal domain complexed with pitstop 2 | x-ray diffraction | A | VH2 | 5 (best 0.77) |
| 6E4L | The structure of the N-terminal domain of human clathrin heavy chain 1 (nTD) in complex with ES9 | x-ray diffraction | A | HRS | 6 (best 0.77) |
| 6E4L | The structure of the N-terminal domain of human clathrin heavy chain 1 (ntd) in complex with ES9 | x-ray diffraction | A | HRS | — |
| 6QNN | Clathrin heavy chain N-terminal domain bound to GTSE1 lidl motif | x-ray diffraction | A | — | 3 (best 0.71) |
| 6QNN | Clathrin heavy chain N-terminal domain bound to GTSE1 lidl motif | x-ray diffraction | A | — | — |
| 6QNP | Clathrin heavy chain N-terminal domain bound to GTSE1 lidl motif | x-ray diffraction | A, B, C, D | — | 15 (best 0.83) |
| 6QNP | Clathrin heavy chain N-terminal domain bound to GTSE1 lidl motif | x-ray diffraction | A, B, C, D | — | — |
| 7BN1 | Clathrin heavy chain N-terminal domain complexed with peptide from Protein mu-NS of Reovirus type 1 | x-ray diffraction | A, B | — | 5 (best 0.83) |
| 7BN1 | Clathrin heavy chain N-terminal domain complexed with peptide from protein mu-ns of reovirus type 1 | x-ray diffraction | A, B | — | — |
| 7BN2 | Clathrin heavy chain N-terminal domain bound to Non structured protein 3 from Eastern Equine… | x-ray diffraction | AAA, BBB | SO4, PO4 | 4 (best 0.82) |
| 7ZX4 | Clathrin N-terminal domain in complex with a HURP phospho-peptide | x-ray diffraction | A, B | CL, NA | 6 (best 0.77) |
| 9C0Y | Clathrin terminal domain complexed with Pitstop 2c | x-ray diffraction | A | A1ATR | 4 (best 0.76) |
| 9C0Z | Clathrin terminal domain complexed with pitstop 2d | x-ray diffraction | A | A1ATQ | 4 (best 0.77) |
| Q00610 | AlphaFold monomer V2.0 prediction for clathrin heavy chain 1 (Q00610) | predicted | A | — | — |
Ligands
- HRS · 5-bromo-N-(4-nitrophenyl)thiophene-2-sulfonamide · in 2 records
- VH1 · 2-(4-aminobenzyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinoline-5-sulfonate · in 2 records
- VH2 · N-[5-[(4-bromophenyl)methyl]-4-hydroxy-1,3-thiazol-2-yl]naphthalene-1-sulfonamide · in 2 records
- A1ATQ · ~{N}-[4-oxidanylidene-5-[(2-phenoxyphenyl)methylidene]-1,3-thiazol-2-yl]naphthalene-1-sulfonamide · in 1 record
- A1ATR · N-{(5Z)-4-oxo-5-[(2-phenoxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-2-yl}naphthalene-2-sulfonamide · in 1 record
- CL · Chloride ion · in 1 record
- NA · Sodium ion · in 1 record
- PO4 · Phosphate ion · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 7ZX4 chain B against the predicted model Q00610: TM-score 0.99, RMSD 0.57 Å
- 6QNP chain A against the predicted model Q00610: TM-score 0.99, RMSD 0.59 Å
- 6QNP chain A against the predicted model Q00610: TM-score 0.99, RMSD 0.59 Å
- 6QNP chain C against the predicted model Q00610: TM-score 0.99, RMSD 0.65 Å
- 6QNP chain C against the predicted model Q00610: TM-score 0.99, RMSD 0.65 Å
- 6QNP chain D against the predicted model Q00610: TM-score 0.99, RMSD 0.65 Å
- 6QNP chain D against the predicted model Q00610: TM-score 0.99, RMSD 0.65 Å
- 6QNP chain B against the predicted model Q00610: TM-score 0.99, RMSD 0.72 Å
- 6QNP chain B against the predicted model Q00610: TM-score 0.99, RMSD 0.72 Å
- 7BN1 chain B against the predicted model Q00610: TM-score 0.99, RMSD 0.74 Å
Elsewhere
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