Research workbench
PI3KC2A core apo
Analyse PI3KC2A core apo in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BI4
- Type
- protein
- Length
- 822 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain- containing subunit…
- EC
- 2.7.1.154
- UniProt
- Q61194
- Ligands
- SO4
- Pockets
- 13 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 4-phosphate 3-kinase C2 domain- containing subunit ALPHA,PHOSPHATIDYLINOSITOL 4-phosphate 3-kinase C2 domain-containing subunit alpha (EC 2.7.1.154) | protein | 822 | 43% helix, 20% strand | Q61194 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 946 | 0.85 | 0.86 | 98 | empty |
| 2 | 652 | 0.72 | 0.79 | 50 | empty |
| 3 | 291 | 0.61 | 0.78 | 30 | EDO |
| 4 | 320 | 0.56 | 0.75 | 40 | empty |
| 5 | 71 | 0.53 | 0.85 | 17 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q61194
- Elsewhere: RCSB PDB 7BI4 · PDBe 7BI4 · UniProt Q61194
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