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HRV14 in complex with its receptor icam-1

Analyse HRV14 in complex with its receptor icam-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7BG7
Type: protein
Length: 885 residues
Chains: 5
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Genome polyprotein; Intercellular adhesion molecule 1
EC: 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48
UniProt: P03303, P05362
Pockets: 13 · best druggability 0.81

Structure

electron microscopy · 5 distinct chains · 9% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
1	Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48)	protein	274	9% helix, 32% strand	P03303
2	Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48)	protein	250	12% helix, 38% strand	P03303
3	Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48)	protein	236	7% helix, 31% strand	P03303
4	Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48)	protein	41	24% helix, 5% strand	P03303
B	Intercellular adhesion molecule 1	protein	84	0% helix, 45% strand	P05362

Pockets

13 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	150	0.81	0.97	26	empty
2	679	0.75	0.81	76	empty
3	156	0.46	0.76	33	empty
4	104	0.43	0.77	26	empty
5	110	0.43	0.77	25	empty

Interfaces

9 interfaces between chains.

1–3 · 4163 Å² buried · 63 hydrogen bonds · protein-protein
1–2 · 2070 Å² buried · 41 hydrogen bonds · protein-protein
2–3 · 1625 Å² buried · 19 hydrogen bonds · protein-protein
1–B · 945 Å² buried · 10 hydrogen bonds · protein-protein
3–4 · 844 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

7BG7 · HRV14 in complex with its receptor ICAM-1 · the same entry in another collection · chain 1 against 1, TM-score 1.00
P05362 · AlphaFold monomer V2.0 prediction for intercellular adhesion molecule 1 (P05362) · a predicted model of the same protein · chain B against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03303
Every structure of UniProt P05362
Elsewhere: RCSB PDB 7BG7 · PDBe 7BG7 · UniProt P03303 · UniProt P05362

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