Research workbench
Fusion of mbp and the backbone of the long-acting amylin analog AM833.
Analyse Fusion of mbp and the backbone of the long-acting amylin analog AM833. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BG0
- Type
- protein
- Length
- 1,541 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MALTOSE/MALTODEXTRIN-binding periplasmic PROTEIN,ISLET amyloid polypeptide
- UniProt
- P0AEX9, P10997
- Ligands
- GLC
- Pockets
- 14 · best druggability 0.86
Structure
x-ray diffraction · 4 distinct chains · 44% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MALTOSE/MALTODEXTRIN-binding periplasmic PROTEIN,ISLET amyloid polypeptide | protein | 403 | 44% helix, 19% strand | P0AEX9, P10997 |
| B | MALTOSE/MALTODEXTRIN-binding periplasmic PROTEIN,ISLET amyloid polypeptide | protein | 371 | 44% helix, 21% strand | P0AEX9 |
| D | MALTOSE/MALTODEXTRIN-binding periplasmic PROTEIN,ISLET amyloid polypeptide | protein | 366 | 44% helix, 21% strand | P0AEX9 |
| E | MALTOSE/MALTODEXTRIN-binding periplasmic PROTEIN,ISLET amyloid polypeptide | protein | 401 | 44% helix, 20% strand | P0AEX9, P10997 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 4 copies · chains A, B, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 882 | 0.86 | 0.88 | 126 | empty |
| 2 | 837 | 0.74 | 0.78 | 81 | empty |
| 3 | 792 | 0.73 | 0.78 | 64 | empty |
| 4 | 209 | 0.72 | 0.88 | 33 | empty |
| 5 | 286 | 0.72 | 0.85 | 30 | GLC |
Interfaces
6 interfaces between chains.
- A–B · 12082 Ų buried · 193 hydrogen bonds · protein-protein
- D–E · 12053 Ų buried · 190 hydrogen bonds · protein-protein
- A–E · 947 Ų buried · 3 hydrogen bonds · protein-protein
- B–E · 558 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 505 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7BG0 · Fusion of MBP and the backbone of the long-acting amylin analog AM833. · the same entry in another collection · chain A against A, TM-score 1.00
- P0AEX9 · AlphaFold monomer V2.0 prediction for MALTOSE/MALTODEXTRIN-binding periplasmic protein… · a predicted model of the same protein · chain B against A, TM-score 0.53
- P10997 · AlphaFold monomer V2.0 prediction for islet amyloid polypeptide (P10997) · a predicted model of the same protein · chain E against A, TM-score 0.11
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEX9
- Every structure of UniProt P10997
- Elsewhere: RCSB PDB 7BG0 · PDBe 7BG0 · UniProt P0AEX9 · UniProt P10997
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