Research workbench
Crystal structure of escherichia COLI sigmae with the cytoplasmic domain of its anti-sigma rsea
Analyse Crystal structure of escherichia COLI sigmae with the cytoplasmic domain of its… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1OR7
- Type
- protein
- Length
- 475 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA polymerase sigma-E factor; Sigma-E factor negative regulatory protein
- UniProt
- P0AGB6, P0AFX7
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 4 distinct chains · 74% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA polymerase sigma-E factor | protein | 181 | 75% helix, 2% strand | P0AGB6 |
| C | Sigma-E factor negative regulatory protein | protein | 66 | 67% helix, 5% strand | P0AFX7 |
| B | RNA polymerase sigma-E factor | protein | 164 | 79% helix, 1% strand | P0AGB6 |
| F | Sigma-E factor negative regulatory protein | protein | 64 | 69% helix, 3% strand | P0AFX7 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 216 | 0.49 | 0.75 | 32 | empty |
| 2 | 56 | 0.35 | 0.78 | 15 | empty |
Interfaces
6 interfaces between chains.
- A–C · 2879 Ų buried · 59 hydrogen bonds · protein-protein
- B–F · 2823 Ų buried · 49 hydrogen bonds · protein-protein
- A–B · 978 Ų buried · 6 hydrogen bonds · protein-protein
- A–F · 238 Ų buried · 1 hydrogen bond · protein-protein
- C–F · 121 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1OR7 · Crystal Structure of Escherichia coli sigmaE with the Cytoplasmic Domain of its… · the same entry in another collection · chain F against F, TM-score 1.00
- P0AFX7 · AlphaFold monomer V2.0 prediction for anti-sigma-E factor rsea (P0AFX7) · a predicted model of the same protein · chain C against A, TM-score 0.89
- P0AGB6 · AlphaFold monomer V2.0 prediction for ecf RNA polymerase sigma-E factor (P0AGB6) · a predicted model of the same protein · chain B against A, TM-score 0.55
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AGB6
- Every structure of UniProt P0AFX7
- Elsewhere: RCSB PDB 1OR7 · PDBe 1OR7 · UniProt P0AGB6 · UniProt P0AFX7
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