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Structural basis of reactivation of oncogenic P53 mutants by a small molecule: methylene quinuclidinone (mq). human wild-type P53DBD bound to DNA and mq: wt-DNA-mq (P1)

Analyse Structural basis of reactivation of oncogenic P53 mutants by a small molecule… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7B46
Type: protein + DNA
Length: 809 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P04637
Ligands: QN8, QNN, ZN

Structure

x-ray diffraction · 6 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	192	—	P04637
B	—	protein	191	—	P04637
C	—	protein	190	—	P04637
D	—	protein	192	—	P04637
E, H	—	dna	11	—	—
F, G	—	dna	11	—	—

Ligands and binding sites

QN8 · (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one · ligand · 7 copies · chains A, E, F, B, C, G, H, D
QNN · (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one · ligand · chains D
ZN · Zinc ion · metal · 4 copies · chains A, B, C, D
ACT · Acetate ion · additive · chains B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7B46 · Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene… · the same entry in another collection · chain H against H, TM-score 1.00

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Every structure of UniProt P04637
Elsewhere: RCSB PDB 7B46 · PDBe 7B46 · UniProt P04637

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