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Crystal structure of R120Q GDAP1 mutant

Analyse Crystal structure of R120Q GDAP1 mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7B2G
Type: protein
Length: 249 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ganglioside-induced differentiation-associated protein 1
UniProt: Q8TB36
Pockets: 5 · best druggability 0.47

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ganglioside-induced differentiation-associated protein 1	protein	249	48% helix, 7% strand	Q8TB36

Ligands and binding sites

GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.47	0.82	11	empty
2	113	0.46	0.78	20	empty
3	69	0.33	0.76	16	empty
4	57	0.27	0.73	14	empty
5	52	0.24	0.72	13	empty

Compared structures

7B2G · Crystal structure of R120Q GDAP1 mutant · the same entry in another collection · chain A against A, TM-score 1.00
Q8TB36 · AlphaFold monomer V2.0 prediction for ganglioside-induced differentiation-associated… · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TB36
Elsewhere: RCSB PDB 7B2G · PDBe 7B2G · UniProt Q8TB36

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