Research workbench
KU70/80 complex apo form
Analyse KU70/80 complex apo form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7AXZ
- Type
- protein
- Length
- 1,023 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- X-ray repair cross-complementing protein 6; X-ray repair cross-complementing protein 5
- EC
- 3.6.4.-, 4.2.99.-
- UniProt
- P12956, P13010
- Pockets
- 13 · best druggability 0.77
Structure
electron microscopy · 2 distinct chains · 29% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | X-ray repair cross-complementing protein 6 (EC 3.6.4.-, 4.2.99.-) | protein | 499 | 29% helix, 20% strand | P12956 |
| B | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) | protein | 524 | 29% helix, 21% strand | P13010 |
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 814 | 0.77 | 0.81 | 99 | empty |
| 2 | 565 | 0.72 | 0.80 | 64 | empty |
| 3 | 252 | 0.65 | 0.82 | 37 | empty |
| 4 | 352 | 0.64 | 0.79 | 36 | empty |
| 5 | 144 | 0.63 | 0.86 | 29 | empty |
Interfaces
1 interface between chains.
- A–B · 9499 Ų buried · 100 hydrogen bonds · protein-protein
Compared structures
- 7AXZ · Ku70/80 complex apo form · the same entry in another collection · chain A against A, TM-score 1.00
- P13010 · AlphaFold monomer V2.0 prediction for X-ray repair cross- complementing protein 5 (P13010) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P12956 · AlphaFold monomer V2.0 prediction for X-ray repair cross- complementing protein 6 (P12956) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12956
- Every structure of UniProt P13010
- Elsewhere: RCSB PDB 7AXZ · PDBe 7AXZ · UniProt P12956 · UniProt P13010
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