Research workbench
The crystal structure of augmenter of liver regeneration: a mammalian FAD dependent sulfhydryl oxidase
Analyse The crystal structure of augmenter of liver regeneration: a mammalian FAD… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1OQC
- Type
- protein
- Length
- 447 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Augmenter of liver regeneration
- UniProt
- Q63042
- Ligands
- FAD
- Pockets
- 4 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D | Augmenter of liver regeneration | protein | 112 | 67% helix, 0% strand | Q63042 |
| B | Augmenter of liver regeneration | protein | 111 | 68% helix, 0% strand | Q63042 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 957 | 0.75 | 0.78 | 91 | FAD |
| 2 | 282 | 0.65 | 0.81 | 39 | FAD |
| 3 | 230 | 0.62 | 0.81 | 39 | FAD |
| 4 | 54 | 0.26 | 0.73 | 17 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1496 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 1448 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 163 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 disulfide (disulfide).
Compared structures
- 1OQC · The crystal structure of augmenter of liver regeneration: a mammalian FAD dependent… · the same entry in another collection · chain A against A, TM-score 1.00
- Q63042 · AlphaFold monomer V2.0 prediction for FAD-linked sulfhydryl oxidase alr (Q63042) · a predicted model of the same protein · chain D against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q63042
- Elsewhere: RCSB PDB 1OQC · PDBe 1OQC · UniProt Q63042
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.