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Crystal structure of the gcd-associated tgfbip mutant R124H

Analyse Crystal structure of the gcd-associated tgfbip mutant R124H in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7AS7
Type: protein
Length: 584 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transforming growth factor-beta-induced protein ig-H3
UniProt: Q15582
Pockets: 4 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transforming growth factor-beta-induced protein ig-H3	protein	584	29% helix, 29% strand	Q15582

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	436	0.62	0.76	57	empty
2	335	0.56	0.75	44	empty
3	122	0.38	0.73	23	empty
4	90	0.36	0.75	19	empty

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

7AS7 · Crystal structure of the GCD-associated TGFBIp mutant R124H · the same entry in another collection · chain A against A, TM-score 1.00
Q15582 · AlphaFold monomer V2.0 prediction for transforming growth factor- beta-induced protein… · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15582
Elsewhere: RCSB PDB 7AS7 · PDBe 7AS7 · UniProt Q15582

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