Research workbench
Human GTP cyclohydrolase I feedback regulatory protein (gfrp) in complex with phenylalanine
Analyse Human GTP cyclohydrolase I feedback regulatory protein (gfrp) in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7AL9
- Type
- protein
- Length
- 830 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTP cyclohydrolase 1 feedback regulatory protein
- UniProt
- P30047
- Ligands
- PHE, K
- Pockets
- 11 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 20% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J | GTP cyclohydrolase 1 feedback regulatory protein | protein | 83 | 20% helix, 43% strand | P30047 |
Ligands and binding sites
- PHE · Phenylalanine · ligand · 10 copies · chains A, D, J, B, C, I, E, F, G, H
- K · Potassium ion · metal · 10 copies · chains A, B, C, D, E, F, G, H, I, J
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 325 | 0.82 | 0.92 | 51 | PHE |
| 2 | 308 | 0.82 | 0.93 | 55 | PHE |
| 3 | 424 | 0.82 | 0.90 | 59 | PHE |
| 4 | 265 | 0.80 | 0.92 | 56 | PHE |
| 5 | 188 | 0.77 | 0.92 | 37 | PHE |
Interfaces
25 interfaces between chains.
- B–I · 1049 Ų buried · 13 hydrogen bonds · protein-protein
- E–G · 1033 Ų buried · 14 hydrogen bonds · protein-protein
- A–J · 991 Ų buried · 11 hydrogen bonds · protein-protein
- F–J · 978 Ų buried · 11 hydrogen bonds · protein-protein
- D–G · 976 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 7AL9 · human GTP cyclohydrolase I feedback regulatory protein (GFRP) in complex with… · the same entry in another collection · chain J against J, TM-score 1.00
- P30047 · AlphaFold monomer V2.0 prediction for GTP cyclohydrolase 1 feedback regulatory protein… · a predicted model of the same protein · chain G against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30047
- Elsewhere: RCSB PDB 7AL9 · PDBe 7AL9 · UniProt P30047
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