Research workbench
HAD7 knob in complex with 2 EC2-EC3 modules of dsg-2
Analyse HAD7 knob in complex with 2 EC2-EC3 modules of dsg-2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7AGG
- Type
- protein
- Length
- 1,056 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fiber; Desmoglein-2
- UniProt
- Q5EY45, Q14126
- Pockets
- 11 · best druggability 0.81
Structure
electron microscopy · 2 distinct chains · 5% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Fiber | protein | 198 | 10% helix, 40% strand | Q5EY45 |
| D, F | Desmoglein-2 | protein | 231 | 1% helix, 33% strand | Q14126 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 589 | 0.81 | 0.86 | 41 | empty |
| 2 | 1167 | 0.77 | 0.79 | 95 | empty |
| 3 | 678 | 0.71 | 0.78 | 58 | empty |
| 4 | 273 | 0.60 | 0.80 | 29 | empty |
| 5 | 153 | 0.49 | 0.77 | 21 | empty |
Interfaces
8 interfaces between chains.
- A–B · 1114 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 1093 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 1076 Ų buried · 7 hydrogen bonds · protein-protein
- B–F · 534 Ų buried · 5 hydrogen bonds · protein-protein
- D–C · 518 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5EY45
- Every structure of UniProt Q14126
- Elsewhere: RCSB PDB 7AGG · PDBe 7AGG · UniProt Q5EY45 · UniProt Q14126
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