UniProt Q14126
Desmoglein-2 (Q14126)
Desmoglein-2 (UniProt Q14126): 14 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q14126
- Protein
- Desmoglein-2
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 27 · 4 records with a druggable one
Structures
15 records of Q14126 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2YQG | Solution structure of the first cadherin domain from human Desmoglein-2 | solution nmr | A | — | — |
| 2YQG | Solution structure of the first cadherin domain from human desmoglein- 2 | solution nmr | A | — | — |
| 5ERD | Crystal structure of human Desmoglein-2 ectodomain | x-ray diffraction | A, B | NAG, MAN, CA | — |
| 5ERD | Crystal structure of human desmoglein-2 ectodomain | x-ray diffraction | A, B | — | — |
| 5J5J | Crystal structure of a chimera of human Desmocollin-2 EC1 and human Desmoglein-2 EC2-EC5 | x-ray diffraction | A | NAG, MAN, CA, CL | 1 (best 0.50) |
| 5J5J | Crystal structure of a chimera of human desmocollin-2 EC1 and human desmoglein-2 EC2-EC5 | x-ray diffraction | A | — | — |
| 6QNT | Human adenovirus type 3 fiber knob in complex with one copy of desmoglein-2 | electron microscopy | D | — | — |
| 6QNU | Human Adenovirus type 3 fiber knob in complex with two copies of Desmoglein-2 | electron microscopy | D, E | — | 8 (best 0.70) |
| 6QNU | Human adenovirus type 3 fiber knob in complex with two copies of desmoglein-2 | electron microscopy | D, E | — | — |
| 6SIT | Pseudo-atomic crystal structure of the desmoglein 2 - human adenovirus serotype 3 fibre knob complex | x-ray diffraction | D | CA | — |
| 7AGF | HAd7 knob in complex with 3 EC2-EC3 modules of DSG-2 | electron microscopy | D, E, F | — | 10 (best 0.79) |
| 7AGF | HAD7 knob in complex with 3 EC2-EC3 modules of dsg-2 | electron microscopy | D, E, F | — | — |
| 7AGG | HAD7 knob in complex with 2 EC2-EC3 modules of dsg-2 | electron microscopy | D, F | — | — |
| 8QJX | Human Adenovirus type 11 fiber knob in complex with two copies of its cell receptor, Desmoglein-2 | electron microscopy | D, E | — | 8 (best 0.81) |
| Q14126 | AlphaFold monomer V2.0 prediction for desmoglein-2 (Q14126) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8QJX chain E against the predicted model Q14126: TM-score 0.98, RMSD 0.77 Å
- 6QNT chain D against the predicted model Q14126: TM-score 0.98, RMSD 0.74 Å
- 8QJX chain D against the predicted model Q14126: TM-score 0.98, RMSD 0.86 Å
- 6SIT chain D against the predicted model Q14126: TM-score 0.97, RMSD 1.04 Å
- 6QNU chain E against the predicted model Q14126: TM-score 0.97, RMSD 0.98 Å
- 6QNU chain E against the predicted model Q14126: TM-score 0.97, RMSD 0.98 Å
- 7AGG chain F against the predicted model Q14126: TM-score 0.96, RMSD 1.19 Å
- 7AGG chain D against the predicted model Q14126: TM-score 0.96, RMSD 1.19 Å
- 7AGF chain E against the predicted model Q14126: TM-score 0.96, RMSD 1.19 Å
- 7AGF chain E against the predicted model Q14126: TM-score 0.96, RMSD 1.19 Å
Elsewhere
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