Wt sting in complex with 3',3'-C-DI[2'FDAM(PS)]

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 26% strand (DSSP).

Ligands and binding sites

• R4T · 9-[(1~{R},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R}, 17~{R},18~{R})-17-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$L^{5},12$L^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-8-yl]purin-6-amine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Compared structures

• 7A90 · WT STING in complex with 3',3'-c-di[2'FdAM(PS)] · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt A0A2R3XZB7
• Elsewhere: RCSB PDB 7A90 · PDBe 7A90 · UniProt A0A2R3XZB7