Ligand · R4T

R4T · 9-[(1~{R},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R}, 17~{R},18~{R})-17-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$L^{5},12$L^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-8-yl]purin-6-amine

R4T, 9-[(1~{R},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R}, 17~{R},18~{R})-17-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$L^{5},12$L^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octa…

Component: R4T
Formula: C20 H24 F2 N10 O8 P2 S2 +2
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

R4T in 2 structures; the first of them:

7A90 · WT STING in complex with 3',3'-c-di[2'FdAM(PS)] · R4T A401 · binds SER162, TYR163, GLY166, TYR167, ARG232, ILE235, ARG238, VAL239 and 5 more
7A90 · Wt sting in complex with 3',3'-C-DI[2'FDAM(PS)] · R4T A401 · binds SER162, TYR163, GLY166, TYR167, ARG232, ILE235, ARG238, TYR240 and 3 more

Residues it binds most

TYR 2, ARG 2, THR 2, SER 2, GLY 2, ILE 2, PRO 2, VAL 1 (residue and the binding sites it lines).

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