Research workbench
Structure of human mitochondrial RNA polymerase in complex with imt inhibitor.
Analyse Structure of human mitochondrial RNA polymerase in complex with imt inhibitor. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7A8P
- Type
- protein
- Length
- 911 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-directed RNA polymerase, mitochondrial
- EC
- 2.7.7.6
- UniProt
- O00411
- Ligands
- R4Q
- Pockets
- 11 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 60% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerase, mitochondrial (EC 2.7.7.6) | protein | 911 | 60% helix, 7% strand | O00411 |
Ligands and binding sites
- R4Q · (3~{R})-1-[(2~{R})-2-[4-(2-chloranyl-4-fluoranyl-phenyl)-2-oxidanylidene-chromen-7-yl]oxypropanoyl]piperidine-3-carboxylic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1144 | 0.84 | 0.85 | 94 | R4Q |
| 2 | 60 | 0.68 | 0.95 | 21 | empty |
| 3 | 634 | 0.68 | 0.77 | 71 | empty |
| 4 | 404 | 0.58 | 0.75 | 43 | empty |
| 5 | 187 | 0.56 | 0.80 | 25 | empty |
Compared structures
- 7A8P · Structure of human mitochondrial RNA polymerase in complex with IMT inhibitor. · the same entry in another collection · chain A against A, TM-score 1.00
- O00411 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase, mitochondrial (O00411) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00411
- Elsewhere: RCSB PDB 7A8P · PDBe 7A8P · UniProt O00411
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