Research workbench
RSGREEN0.7-K206A-E222V in the green-on state
Analyse RSGREEN0.7-K206A-E222V in the green-on state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7A80
- Type
- protein
- Length
- 905 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Green fluorescent protein
- UniProt
- A0A059PIQ0
- Ligands
- CRO, NO3
- Pockets
- 11 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 11% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Green fluorescent protein | protein | 226 | 11% helix, 52% strand | A0A059PIQ0 |
| D | Green fluorescent protein | protein | 227 | 11% helix, 52% strand | A0A059PIQ0 |
Ligands and binding sites
- CRO · {2-[(1R,2R)-1-amino-2-hydroxypropyl]-4-(4-hydroxybenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · 4 copies · chains A, B, C, D
- NO3 · Nitrate ion · ion · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 134 | 0.80 | 0.97 | 28 | CRO |
| 2 | 136 | 0.80 | 0.97 | 30 | CRO |
| 3 | 130 | 0.79 | 0.96 | 28 | CRO |
| 4 | 121 | 0.78 | 0.97 | 26 | CRO |
| 5 | 188 | 0.48 | 0.76 | 43 | empty |
Interfaces
2 interfaces between chains.
- C–D · 818 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 758 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 cofactor (chromophore).
Compared structures
- 7A80 · rsGreen0.7-K206A-E222V in the green-on state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A059PIQ0
- Elsewhere: RCSB PDB 7A80 · PDBe 7A80 · UniProt A0A059PIQ0
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