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Structure of 14-3-3 gamma in complex with DAPK2 peptide containing the 14-3-3 binding motif
Analyse Structure of 14-3-3 gamma in complex with DAPK2 peptide containing the 14-3-3… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7A6R
- Type
- protein
- Length
- 938 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 14-3-3 protein gamma; DAPK2 C-terminal peptide
- UniProt
- P61981
- Pockets
- 10 · best druggability 0.74
Structure
x-ray diffraction · 7 distinct chains · 82% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 14-3-3 protein gamma | protein | 227 | 83% helix, 0% strand | P61981 |
| B | 14-3-3 protein gamma | protein | 222 | 81% helix, 0% strand | P61981 |
| C | 14-3-3 protein gamma | protein | 233 | 84% helix, 0% strand | P61981 |
| D | 14-3-3 protein gamma | protein | 232 | 85% helix, 0% strand | P61981 |
| E, G | DAPK2 C-terminal peptide | protein | 6 | 0% helix, 0% strand | — |
| F | DAPK2 C-terminal peptide | protein | 7 | 0% helix, 0% strand | — |
| L | DAPK2 C-terminal peptide | protein | 5 | 0% helix, 0% strand | — |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 976 | 0.74 | 0.77 | 78 | empty |
| 2 | 594 | 0.68 | 0.77 | 58 | empty |
| 3 | 94 | 0.58 | 0.86 | 18 | empty |
| 4 | 387 | 0.58 | 0.76 | 27 | empty |
| 5 | 155 | 0.46 | 0.76 | 19 | empty |
Interfaces
11 interfaces between chains.
- A–C · 1075 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 947 Ų buried · 6 hydrogen bonds · protein-protein
- B–F · 615 Ų buried · 23 hydrogen bonds · protein-protein
- A–E · 512 Ų buried · 13 hydrogen bonds · protein-protein
- C–G · 499 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (phosphorylation).
Compared structures
- 7A6R · Structure of 14-3-3 gamma in complex with DAPK2 peptide containing the 14-3-3 binding… · the same entry in another collection · chain L against L, TM-score 1.00
- P61981 · AlphaFold monomer V2.0 prediction for 14-3-3 protein gamma (P61981) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61981
- Elsewhere: RCSB PDB 7A6R · PDBe 7A6R · UniProt P61981
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