UniProt P61981

14-3-3 protein gamma (P61981)

14-3-3 protein gamma (UniProt P61981): 36 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 85 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P61981
Protein: 14-3-3 protein gamma
Experimental structures: 36
Predicted models: 1
Ligands: 6
Pockets: 85 · 8 records with a druggable one

Structures

37 records of P61981 in the MolNFT archive: 36 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
2B05	Crystal Structure of 14-3-3 gamma in complex with a phosphoserine peptide	x-ray diffraction	A, B, C, D, E, F	—	—
2B05	Crystal structure of 14-3-3 gamma in complex with a phosphoserine peptide	x-ray diffraction	A, B, C, D, E, F	—	—
3UZD	Crystal structure of 14-3-3 GAMMA	x-ray diffraction	A	—	—
3UZD	Crystal structure of 14-3-3 gamma	x-ray diffraction	A	—	—
4E2E	Crystal structure of a tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein…	x-ray diffraction	A	—	—
4E2E	Crystal structure of a tyrosine 3-MONOOXYGENASE/TRYPTOPHAN 5- monooxygenase activation protein…	x-ray diffraction	A	—	—
4J6S	14-3-3gamma complexed with the N-terminal sequence of tyrosine hydroxylase (residues 1-43)	x-ray diffraction	A, B, C, D	—	—
4J6S	14-3-3GAMMA complexed with the N-terminal sequence of tyrosine hydroxylase (residues 1-43)	x-ray diffraction	A, B, C, D	—	—
4O46	14-3-3-gamma in complex with influenza NS1 C-terminal tail phosphorylated at S228	x-ray diffraction	A, B, C, D, E, F	—	—
4O46	14-3-3-gamma in complex with influenza NS1 C-terminal tail phosphorylated at S228	x-ray diffraction	A, B, C, D, E, F	—	—
5D3E	Crystal structure of human 14-3-3 gamma in complex with CFTR R-domain peptide pS768-pS795	x-ray diffraction	A, B, E, F, I, J	—	20 (best 0.71)
5D3E	Crystal structure of human 14-3-3 gamma in complex with cftr R-domain peptide PS768-PS795	x-ray diffraction	A, B, E, F, I, J	—	—
6A5S	Structure of 14-3-3 gamma in complex with tfeb 14-3-3 binding motif	x-ray diffraction	A, B, D, G	NA, MG	—
6BYJ	Structure of human 14-3-3 gamma bound to O-GlcNAc peptide	x-ray diffraction	A, B, C, D, E, F	NAG	—
6BYJ	Structure of human 14-3-3 gamma bound to O-glcnac peptide	x-ray diffraction	A, B, C, D, E, F	NAG	—
6BYL	Structure of 14-3-3 gamma bound to O-GlcNAcylated thr peptide	x-ray diffraction	A, B, C, D, E, F	NAG	16 (best 0.67)
6BYL	Structure of 14-3-3 gamma bound to O-glcnacylated thr peptide	x-ray diffraction	A, B, C, D, E, F	NAG	—
6BZD	Structure of 14-3-3 gamma R57E mutant bound to GlcNAcylated peptide	x-ray diffraction	A, B, C, D	NAG	5 (best 0.53)
6BZD	Structure of 14-3-3 gamma R57E mutant bound to glcnacylated peptide	x-ray diffraction	A, B, C, D	NAG	—
6FEL	Structure of 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser511	x-ray diffraction	A, C, B, D	—	9 (best 0.72)
6FEL	Structure of 14-3-3 gamma in complex with CAMKK2 14-3-3 binding motif SER511	x-ray diffraction	A, C, B, D	—	—
6GKF	Structure of 14-3-3 gamma in complex with caspase-2 14-3-3 binding motif SER139	x-ray diffraction	A, C, E, G, B, D, F, H	—	—
6GKG	Structure of 14-3-3 gamma in complex with caspase-2 14-3-3 binding motif Ser164	x-ray diffraction	A, B, C, D, E, F, G, H	—	—
6GKG	Structure of 14-3-3 gamma in complex with caspase-2 14-3-3 binding motif SER164	x-ray diffraction	A, B, C, D, E, F, G, H	—	—
6S9K	Structure of 14-3-3 gamma in complex with caspase-2 peptide containing 14-3-3 binding motif Ser139…	x-ray diffraction	A	CFH	2 (best 0.61)
6S9K	Structure of 14-3-3 gamma in complex with caspase-2 peptide containing 14-3-3 binding motif SER139…	x-ray diffraction	A	CFH	—
6SAD	Structure of 14-3-3 gamma in complex with double phosphorylated caspase-2 peptide on SER139 and…	x-ray diffraction	A, B	—	—
6Y4K	Crystal structure of human 14-3-3 gamma in complex with CAMKK2 14-3-3 binding motif SER100 and…	x-ray diffraction	A, B	FSC	—
6Y6B	Crystal structure of human 14-3-3 gamma in complex with CAMKK2 14-3-3 binding motif SER100 and…	x-ray diffraction	A, B	OD8	—
6ZBT	Structure of 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser342	x-ray diffraction	A, B, C, D	CFH	14 (best 0.68)
6ZBT	Structure of 14-3-3 gamma in complex with NEDD4-2 14-3-3 binding motif SER342	x-ray diffraction	A, B, C, D	CFH	—
6ZC9	Structure of 14-3-3 gamma in complex with NEDD4-2 14-3-3 binding motif SER448	x-ray diffraction	A, B, C, D	CFH	—
7A6R	Structure of 14-3-3 gamma in complex with DAPK2 peptide containing the 14-3-3 binding motif	x-ray diffraction	A, B, C, D	—	10 (best 0.74)
7A6R	Structure of 14-3-3 gamma in complex with DAPK2 peptide containing the 14-3-3 binding motif	x-ray diffraction	A, B, C, D	—	—
7A6Y	Structure of 14-3-3 gamma in complex with DAPK2 peptide stabilized by FC-A	x-ray diffraction	A, B, C, D	FSC	9 (best 0.71)
7A6Y	Structure of 14-3-3 gamma in complex with DAPK2 peptide stabilized by Fc-a	x-ray diffraction	A, B, C, D	FSC	—
P61981	AlphaFold monomer V2.0 prediction for 14-3-3 protein gamma (P61981)	predicted	A	—	—

Ligands

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 6 records
CFH · 1,1,1,3,3,3-hexafluoropropan-2-ol · in 5 records
FSC · Fusicoccin · in 3 records
MG · Magnesium ion · in 1 record
NA · Sodium ion · in 1 record
OD8 · (2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[[(1~{S},3~{R},6~{S},7~{S},8~{R},9~{R},10~{R},11~{R}, 14~{S})-14-(me thoxymethyl)-3,10-dimethyl-9-oxidanyl-6-propan-2-yl-8-tricyclo[9.3.0.0^{3, 7}]tetradecanyl]oxy]oxane-3,4,5-triol · in 1 record

Experiment against prediction

2B05 chain E against the predicted model P61981: TM-score 0.99, RMSD 0.44 Å
2B05 chain E against the predicted model P61981: TM-score 0.99, RMSD 0.44 Å
2B05 chain D against the predicted model P61981: TM-score 0.99, RMSD 0.45 Å
2B05 chain D against the predicted model P61981: TM-score 0.99, RMSD 0.45 Å
2B05 chain B against the predicted model P61981: TM-score 0.99, RMSD 0.46 Å
2B05 chain B against the predicted model P61981: TM-score 0.99, RMSD 0.46 Å
2B05 chain F against the predicted model P61981: TM-score 0.99, RMSD 0.46 Å
2B05 chain F against the predicted model P61981: TM-score 0.99, RMSD 0.46 Å
2B05 chain C against the predicted model P61981: TM-score 0.99, RMSD 0.48 Å
2B05 chain C against the predicted model P61981: TM-score 0.99, RMSD 0.48 Å

Elsewhere

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