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TRNA-guanine transglycosylase C158S/C281S/Y330C/H333A mutant in complex with 3-hydroxysulfolane

Analyse TRNA-guanine transglycosylase C158S/C281S/Y330C/H333A mutant in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7A3V
Type: protein
Length: 371 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Queuine tRNA-ribosyltransferase
EC: 2.4.2.29
UniProt: P28720
Ligands: QXE, ZN
Pockets: 4 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Queuine tRNA-ribosyltransferase (EC 2.4.2.29)	protein	371	46% helix, 19% strand	P28720

Ligands and binding sites

QXE · 3-hydroxythietane-1,1-dioxide · ligand · 2 copies · chains A
ZN · Zinc ion · metal · chains A
GOL · Glycerol · additive · 2 copies · chains A
EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	261	0.71	0.86	51	empty
2	125	0.45	0.77	18	QXE
3	56	0.40	0.81	12	EDO
4	50	0.26	0.73	10	QXE

Compared structures

7A3V · tRNA-guanine transglycosylase C158S/C281S/Y330C/H333A mutant in complex with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P28720
Elsewhere: RCSB PDB 7A3V · PDBe 7A3V · UniProt P28720

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