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Crystal structure of the fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex with VSL12 at pH 4.0

Analyse Crystal structure of the fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7A2Y
Type: protein
Length: 72 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein kinase fyn; VSL12
EC: 2.7.10.2
UniProt: P06241

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein kinase fyn (EC 2.7.10.2)	protein	60	5% helix, 43% strand	P06241
B	VSL12	protein	12	25% helix, 0% strand	—

Ligands and binding sites

ACT · Acetate ion · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 562 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent (additive adduct).

Compared structures

7A2Y · Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex… · the same entry in another collection · chain A against A, TM-score 1.00
P06241 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase fyn (P06241) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06241
Elsewhere: RCSB PDB 7A2Y · PDBe 7A2Y · UniProt P06241

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