Research workbench

Outer dynein arm-shulin complex - shulin region from tetrahymena thermophila

Analyse Outer dynein arm-shulin complex - shulin region from tetrahymena thermophila in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6ZYX
Type: protein
Length: 2,067 residues
Chains: 10
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dynein heavy chain, outer arm protein; Dynein light chain; Dynein light chain 2A; Dynein…
UniProt: Q22A67, Q24DI9, Q22R86, W7XJB1, Q24CE5, Q1HGH8, A4VEB3, Q22YU3, I7M008, Q23FU1
Ligands: GTP
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 10 distinct chains · 41% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	Dynein heavy chain, outer arm protein	protein	278	80% helix, 0% strand	Q22A67
J	Dynein light chain	protein	84	35% helix, 37% strand	Q24DI9
K	Dynein light chain	protein	95	34% helix, 32% strand	Q22R86
L	Dynein light chain	protein	97	30% helix, 36% strand	W7XJB1
M	Dynein light chain	protein	86	37% helix, 35% strand	Q24CE5
N	Dynein light chain 2A	protein	109	33% helix, 24% strand	Q1HGH8
O	Dynein light chain tctex-type 1 protein	protein	111	33% helix, 28% strand	A4VEB3
Y	Shulin	protein	1067	39% helix, 18% strand	Q22YU3
d	Dynein intermediate chain 2	protein	91	21% helix, 14% strand	I7M008
e	Flagellar outer dynein arm intermediate protein, putative	protein	49	0% helix, 18% strand	Q23FU1

Ligands and binding sites

GTP · Guanosine-5'-triphosphate · ligand · chains Y

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1189	0.82	0.83	108	empty
2	1104	0.81	0.82	101	empty
3	956	0.79	0.81	94	empty
4	685	0.79	0.84	80	GTP
5	774	0.76	0.80	78	empty

Interfaces

31 interfaces between chains.

N–O · 1601 Å² buried · 22 hydrogen bonds · protein-protein
C–Y · 1214 Å² buried · 3 hydrogen bonds · protein-protein
M–d · 1149 Å² buried · 9 hydrogen bonds · protein-protein
N–d · 1026 Å² buried · 11 hydrogen bonds · protein-protein
J–K · 944 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

6ZYX · Outer Dynein Arm-Shulin complex - Shulin region from Tetrahymena thermophila · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q22A67
Every structure of UniProt Q24DI9
Every structure of UniProt Q22R86
Every structure of UniProt W7XJB1
Every structure of UniProt Q24CE5
Every structure of UniProt Q1HGH8
Every structure of UniProt A4VEB3
Every structure of UniProt Q22YU3
Every structure of UniProt I7M008
Every structure of UniProt Q23FU1
Elsewhere: RCSB PDB 6ZYX · PDBe 6ZYX · UniProt Q22A67 · UniProt Q24DI9 · UniProt Q22R86 · UniProt W7XJB1 · UniProt Q24CE5 · UniProt Q1HGH8 · UniProt A4VEB3 · UniProt Q22YU3 · UniProt I7M008 · UniProt Q23FU1

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