Research workbench
Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1A) arrangement
Analyse Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ZXL
- Type
- protein
- Length
- 5,772 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protective antigen; Lethal factor
- EC
- 3.4.24.83
- UniProt
- Q68GS1, P15917
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 5 distinct chains · 40% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, E, F, G | Protective antigen | protein | 529 | 19% helix, 30% strand | Q68GS1 |
| D | Protective antigen | protein | 528 | 17% helix, 30% strand | Q68GS1 |
| H | Lethal factor (EC 3.4.24.83) | protein | 699 | 52% helix, 10% strand | P15917 |
| I | Lethal factor (EC 3.4.24.83) | protein | 710 | 51% helix, 14% strand | P15917 |
| J | Lethal factor (EC 3.4.24.83) | protein | 661 | 51% helix, 14% strand | P15917 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 666 | 0.84 | 0.88 | 82 | empty |
| 2 | 880 | 0.84 | 0.86 | 99 | empty |
| 3 | 820 | 0.84 | 0.86 | 90 | empty |
| 4 | 745 | 0.84 | 0.87 | 94 | empty |
| 5 | 278 | 0.83 | 0.94 | 51 | empty |
Interfaces
15 interfaces between chains.
- E–F · 1386 Ų buried · 11 hydrogen bonds · protein-protein
- F–G · 1302 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 1278 Ų buried · 10 hydrogen bonds · protein-protein
- D–E · 1270 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 1266 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6ZXL · Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1A)… · the same entry in another collection · chain J against J, TM-score 1.00
- P15917 · AlphaFold monomer V2.0 prediction for lethal factor (P15917) · a predicted model of the same protein · chain H against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q68GS1
- Every structure of UniProt P15917
- Elsewhere: RCSB PDB 6ZXL · PDBe 6ZXL · UniProt Q68GS1 · UniProt P15917
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