UniProt P15917
Lethal factor (P15917)
Lethal factor (UniProt P15917), EC 3.4.24.83: 61 experimental structures on GenesisL1, 4 ligands bound, 39 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P15917
- Protein
- Lethal factor
- EC
- 3.4.24.83
- Experimental structures
- 61
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 39 · 7 records with a druggable one
Structures
61 records of P15917 in the MolNFT archive: 61 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1J7N | Anthrax Toxin Lethal factor | x-ray diffraction | A, B | — | — |
| 1J7N | Anthrax toxin lethal factor | x-ray diffraction | A, B | — | — |
| 1JKY | Crystal Structure of the Anthrax Lethal Factor (LF): Wild-type LF Complexed with the N-terminal… | x-ray diffraction | A | — | — |
| 1JKY | Crystal structure of the anthrax lethal factor (lf): wild-type lf complexed with the N-terminal… | x-ray diffraction | A | — | — |
| 1PWP | Crystal Structure of the Anthrax Lethal Factor complexed with Small Molecule Inhibitor NSC 12155 | x-ray diffraction | A, B | — | — |
| 1PWP | Crystal structure of the anthrax lethal factor complexed with small molecule inhibitor nsc 12155 | x-ray diffraction | A, B | — | — |
| 1PWQ | Crystal structure of Anthrax Lethal Factor complexed with Thioacetyl-Tyr-Pro-Met-Amide, a… | x-ray diffraction | A, B | — | — |
| 1PWQ | Crystal structure of anthrax lethal factor complexed with thioacetyl-tyr-pro-met-amide, a… | x-ray diffraction | A, B | — | — |
| 1PWU | Crystal Structure of Anthrax Lethal Factor complexed with… | x-ray diffraction | A, B | — | — |
| 1PWU | Crystal structure of anthrax lethal factor complexed with (3-(N… | x-ray diffraction | A, B | — | — |
| 1PWV | Crystal structure of Anthrax Lethal Factor wild-type protein complexed with an optimised peptide… | x-ray diffraction | A, B | — | — |
| 1PWV | Crystal structure of anthrax lethal factor wild-type protein complexed with an optimised peptide… | x-ray diffraction | A, B | — | — |
| 1PWW | Crystal structure of Anthrax Lethal Factor active site mutant protein complexed with an optimised… | x-ray diffraction | A, B | — | — |
| 1PWW | Crystal structure of anthrax lethal factor active site mutant protein complexed with an optimised… | x-ray diffraction | A, B | — | — |
| 1YQY | Structure of B. Anthrax Lethal factor in complex with a hydroxamate inhibitor | x-ray diffraction | A | — | — |
| 1YQY | Structure of B. anthrax lethal factor in complex with a hydroxamate inhibitor | x-ray diffraction | A | — | — |
| 2L0R | Conformational Dynamics of the Anthrax Lethal Factor Catalytic Center | solution nmr | A | — | — |
| 2L0R | Conformational dynamics of the anthrax lethal factor catalytic center | solution nmr | A | — | — |
| 3KWV | Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers | x-ray diffraction | C, F | — | — |
| 3KWV | Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers | x-ray diffraction | C, F | — | — |
| 4DV8 | Anthrax Lethal Factor metalloproteinase in complex with the Hydroxamic acid based small molecule… | x-ray diffraction | A | — | — |
| 4DV8 | Anthrax lethal factor metalloproteinase in complex with the hydroxamic acid based small molecule… | x-ray diffraction | A | — | — |
| 4PKQ | Anthrax toxin lethal factor with bound zinc | x-ray diffraction | A | — | — |
| 4PKQ | Anthrax toxin lethal factor with bound zinc | x-ray diffraction | A | — | — |
| 4PKR | Anthrax toxin lethal factor with bound small molecule inhibitor 10 | x-ray diffraction | A | — | — |
| 4PKR | Anthrax toxin lethal factor with bound small molecule inhibitor 10 | x-ray diffraction | A | — | — |
| 4PKS | Anthrax toxin lethal factor with bound small molecule inhibitor 11 | x-ray diffraction | A | — | — |
| 4PKS | Anthrax toxin lethal factor with bound small molecule inhibitor 11 | x-ray diffraction | A | — | — |
| 4PKT | Anthrax toxin lethal factor with bound small molecule inhibitor 13 | x-ray diffraction | A | — | — |
| 4PKT | Anthrax toxin lethal factor with bound small molecule inhibitor 13 | x-ray diffraction | A | — | — |
| 4PKU | Anthrax toxin lethal factor with bound small molecule inhibitor 15 | x-ray diffraction | A | — | — |
| 4PKU | Anthrax toxin lethal factor with bound small molecule inhibitor 15 | x-ray diffraction | A | — | — |
| 4PKV | Anthrax toxin lethal factor with bound small molecule inhibitor 16 | x-ray diffraction | A | — | — |
| 4PKV | Anthrax toxin lethal factor with bound small molecule inhibitor 16 | x-ray diffraction | A | — | — |
| 4PKW | Anthrax toxin lethal factor with bound small molecule inhibitor GM6001 | x-ray diffraction | A | — | — |
| 4PKW | Anthrax toxin lethal factor with bound small molecule inhibitor GM6001 | x-ray diffraction | A | — | — |
| 4WF6 | Anthrax toxin lethal factor with bound small molecule inhibitor MK-31 | x-ray diffraction | A | — | — |
| 4WF6 | Anthrax toxin lethal factor with bound small molecule inhibitor mk-31 | x-ray diffraction | A | — | — |
| 4XM6 | Anthrax toxin lethal factor with ligand-induced binding pocket | x-ray diffraction | A | — | — |
| 4XM6 | Anthrax toxin lethal factor with ligand-induced binding pocket | x-ray diffraction | A | — | — |
| 4XM7 | Anthrax toxin lethal factor with ligand-induced binding pocket | x-ray diffraction | A | — | — |
| 4XM7 | Anthrax toxin lethal factor with ligand-induced binding pocket | x-ray diffraction | A | — | — |
| 4XM8 | Anthrax toxin lethal factor with ligand-induced binding pocket | x-ray diffraction | A | — | — |
| 4XM8 | Anthrax toxin lethal factor with ligand-induced binding pocket | x-ray diffraction | A | — | — |
| 5D1S | Anthrax toxin lethal factor with hydroxamic acid inhibitor | x-ray diffraction | A | 56Q, ZN | 3 (best 0.79) |
| 5D1S | Anthrax toxin lethal factor with hydroxamic acid inhibitor | x-ray diffraction | A | — | — |
| 5D1T | Anthrax toxin lethal factor with hydroxamic acid inhibitor | x-ray diffraction | A | ZN, 56R | 4 (best 0.71) |
| 5D1T | Anthrax toxin lethal factor with hydroxamic acid inhibitor | x-ray diffraction | A | — | — |
| 5D1U | Anthrax toxin lethal factor with hydroxamic acid inhibitor | x-ray diffraction | A | 56P, ZN | — |
| 5D1U | Anthrax toxin lethal factor with hydroxamic acid inhibitor | x-ray diffraction | A | — | — |
| 6PSN | Anthrax toxin protective antigen channels bound to lethal factor | electron microscopy | L | — | 1 (best 0.68) |
| 6PSN | Anthrax toxin protective antigen channels bound to lethal factor | electron microscopy | L | — | — |
| 6ZXJ | Fully-loaded anthrax lethal toxin in its heptameric pre-pore state, in which the third lethal… | electron microscopy | H, I | — | — |
| 6ZXK | Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1B) arrangement | electron microscopy | H, I, J | — | 9 (best 0.85) |
| 6ZXK | Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1B) arrangement | electron microscopy | H, I, J | — | — |
| 6ZXL | Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1A) arrangement | electron microscopy | H, I, J | — | 8 (best 0.84) |
| 6ZXL | Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1A) arrangement | electron microscopy | H, I, J | — | — |
| 7KXR | Protective antigen pore translocating lethal factor N-terminal domain | electron microscopy | L | — | 8 (best 0.88) |
| 7KXR | Protective antigen pore translocating lethal factor N-terminal domain | electron microscopy | L | — | — |
| 8FVU | Cryo-EM structure of human Needle/NAIP/NLRC4 (R288A) | electron microscopy | U | — | 6 (best 0.77) |
1 record more on the page itself.
Ligands
- ZN · Zinc ion · in 3 records
- 56P · N~2~-(6-aminohexyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide · in 1 record
- 56Q · N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-methyl-D-alaninamide · in 1 record
- 56R · N~2~-[3-(aminomethyl)benzyl]-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide · in 1 record
Elsewhere
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