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Ligand · GM6

GM6 · 3-(N-hydroxycarboxamido)-2-isobutylpropanoyl-trp-methylamide

GM6, 3-(N-hydroxycarboxamido)-2-isobutylpropanoyl-trp-methylamide (C20 H28 N4 O4, 388.5 g/mol), in the MolNFT structures on GenesisL1: bound in 12 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the residues it…

Component
GM6
Formula
C20 H28 N4 O4
Class
ligand
Structures
12
PDB entries
6

Binding sites

GM6 in 12 structures; the first of them:

  • 1PWU · Crystal Structure of Anthrax Lethal Factor complexed with… · GM6 A1001 · binds ASP328, PHE329, VAL653, HIS654, SER655, LYS656, GLY657, LEU658 and 12 more
  • 2DW0 · Crystal structure of VAP2 from Crotalus atrox venom (Form 2-1 crystal) · GM6 A901 · binds ARG297, VAL298, ILE299, GLY300, LEU301, ALA302, TYR320, ILE330 and 8 more
  • 2DW1 · Crystal structure of VAP2 from Crotalus atrox venom (Form 2-2 crystal) · GM6 A2 · binds ARG297, VAL298, ILE299, GLY300, LEU301, ALA302, TYR320, ILE330 and 8 more
  • 2E3X · Crystal structure of Russell's viper venom metalloproteinase · GM6 A507 · binds ASN109, THR110, LEU111, GLY112, ILE142, HIS145, GLU146, HIS149 and 5 more
  • 2ERP · Crystal structure of vascular apoptosis-inducing protein-1(inhibitor-bound form) · GM6 A1002 · binds PRO299, THR300, ALA301, GLY302, LEU303, GLY304, ALA332, HIS335 and 8 more
  • 4PKW · Anthrax toxin lethal factor with bound small molecule inhibitor GM6001 · GM6 A802 · binds ASP328, PHE329, VAL653, HIS654, SER655, LYS656, GLY657, LEU658 and 12 more
  • 1PWU · Crystal structure of anthrax lethal factor complexed with (3-(N… · GM6 A1001 · binds ASP328, PHE329, VAL653, HIS654, SER655, LYS656, GLY657, LEU658 and 12 more
  • 2DW0 · Crystal structure of VAP2 from crotalus atrox venom (form 2-1 crystal) · GM6 A901 · binds ARG297, VAL298, ILE299, GLY300, LEU301, ALA302, TYR320, ILE330 and 8 more
  • 2DW1 · Crystal structure of VAP2 from crotalus atrox venom (form 2-2 crystal) · GM6 A2 · binds ARG297, VAL298, ILE299, GLY300, LEU301, ALA302, TYR320, ILE330 and 8 more
  • 2E3X · Crystal structure of RUSSELL'S viper venom metalloproteinase · GM6 A507 · binds ASN109, THR110, LEU111, GLY112, ILE142, HIS145, GLU146, HIS149 and 5 more
  • 2ERP · Crystal structure of vascular apoptosis-inducing protein-1(INHIBITOR- bound form) · GM6 A1002 · binds PRO299, THR300, ALA301, GLY302, LEU303, GLY304, ALA332, HIS335 and 8 more
  • 4PKW · Anthrax toxin lethal factor with bound small molecule inhibitor GM6001 · GM6 A802 · binds ASP328, PHE329, VAL653, HIS654, SER655, LYS656, GLY657, LEU658 and 12 more

Residues it binds most

HIS 20, GLU 20, GLY 20, LEU 20, ILE 10, ALA 10, VAL 16, TYR 14, ARG 8, LYS 10 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • CA · Calcium ion
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • MAN · alpha-D-mannopyranose
  • BMA · beta-D-mannopyranose
  • 3CO · Cobalt (III) ion
  • FUC · alpha-L-fucopyranose
  • EDO · 1,2-ethanediol
  • GOL · Glycerol

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