Research workbench
High-resolution solution structure of the oligomerization domain of P53 by multi-dimensional NMR
Analyse High-resolution solution structure of the oligomerization domain of P53 by… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1OLH
- Type
- protein
- Length
- 168 residues
- Chains
- 4
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tumor suppressor P53 (oligomerization domain)
- UniProt
- P04637
- Pockets
- 3 · best druggability 0.43
Structure
solution nmr · 1 distinct chain · 48% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Tumor suppressor P53 (oligomerization domain) | protein | 42 | 48% helix, 12% strand | P04637 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.43 | 0.79 | 16 | empty |
| 2 | 79 | 0.40 | 0.78 | 15 | empty |
| 3 | 84 | 0.36 | 0.76 | 18 | empty |
Interfaces
6 interfaces between chains.
- A–C · 1269 Ų buried · 24 hydrogen bonds · protein-protein
- B–D · 1227 Ų buried · 24 hydrogen bonds · protein-protein
- C–D · 368 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 311 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 99 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1OLH · High-resolution solution structure of the oligomerization domain of P53 by… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04637
- Elsewhere: RCSB PDB 1OLH · PDBe 1OLH · UniProt P04637
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