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X-ray diffraction structure of bovine insulin at 2.3 a resolution

Analyse X-ray diffraction structure of bovine insulin at 2.3 a resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6ZI8
Type: protein
Length: 99 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin
UniProt: P01317
Ligands: ZN, CL

Structure

x-ray diffraction · 3 distinct chains · 51% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Insulin	protein	21	57% helix, 10% strand	P01317
B	Insulin	protein	29	48% helix, 14% strand	P01317
D	Insulin	protein	28	50% helix, 14% strand	P01317

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains B, D
CL · Chloride ion · ion · 2 copies · chains B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

5 interfaces between chains.

A–B · 870 Å² buried · 10 hydrogen bonds · protein-protein
C–D · 823 Å² buried · 10 hydrogen bonds · protein-protein
B–D · 621 Å² buried · 8 hydrogen bonds · protein-protein
B–C · 59 Å² buried · 1 hydrogen bond · protein-protein
A–D · 55 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

6ZI8 · X-ray diffraction structure of bovine insulin at 2.3 A resolution · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01317
Elsewhere: RCSB PDB 6ZI8 · PDBe 6ZI8 · UniProt P01317

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