Research workbench
Structure of the plasmodium falciparum HSP70-X substrate binding domain in complex with hydrophobic peptide
Analyse Structure of the plasmodium falciparum HSP70-X substrate binding domain in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ZHI
- Type
- protein
- Length
- 883 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock protein 70; Asn-arg-leu-leu-leu-thr-gly
- UniProt
- K7NTP5
- Pockets
- 15 · best druggability 0.77
Structure
x-ray diffraction · 6 distinct chains · 41% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat shock protein 70 | protein | 218 | 41% helix, 28% strand | K7NTP5 |
| B | Heat shock protein 70 | protein | 222 | 41% helix, 27% strand | K7NTP5 |
| C | Heat shock protein 70 | protein | 213 | 41% helix, 27% strand | K7NTP5 |
| D | Heat shock protein 70 | protein | 205 | 43% helix, 25% strand | K7NTP5 |
| E, F, G | Asn-arg-leu-leu-leu-thr-gly | protein | 7 | 0% helix, 43% strand | — |
| H | Asn-arg-leu-leu-leu-thr-gly | protein | 4 | 0% helix, 25% strand | — |
Pockets
15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1136 | 0.77 | 0.79 | 96 | empty |
| 2 | 677 | 0.70 | 0.77 | 42 | empty |
| 3 | 761 | 0.68 | 0.75 | 76 | empty |
| 4 | 473 | 0.64 | 0.77 | 57 | empty |
| 5 | 298 | 0.54 | 0.75 | 25 | empty |
Interfaces
10 interfaces between chains.
- A–D · 713 Ų buried · 7 hydrogen bonds · protein-protein
- B–G · 606 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 602 Ų buried · 7 hydrogen bonds · protein-protein
- C–F · 587 Ų buried · 9 hydrogen bonds · protein-protein
- A–E · 584 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6ZHI · Structure of the Plasmodium falciparum Hsp70-x substrate binding domain in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt K7NTP5
- Elsewhere: RCSB PDB 6ZHI · PDBe 6ZHI · UniProt K7NTP5
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