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Cryo-EM structure of DNA-pkcs (state 1)

Analyse Cryo-EM structure of DNA-pkcs (state 1) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6ZH2
Type: protein
Length: 3,704 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA-dependent protein kinase catalytic SUBUNIT,DNA- dependent protein kinase catalytic…
EC: 2.7.11.1
UniProt: P78527
Pockets: 20 · best druggability 0.86

Structure

electron microscopy · 1 distinct chain · 61% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA-dependent protein kinase catalytic SUBUNIT,DNA- dependent protein kinase catalytic SUBUNIT,DNA-dependent protein kinase catalytic SUBUNIT,DNA-dependent protein kinase catalytic SUBUNIT,DNA-dependent protein kinase catalytic SUBUNIT,DNA-dependent protein kinase catalytic SUBUNIT,DNA-dependent protein kinase catalytic SUBUNIT,DNA-dependent protein kinase catalytic SUBUNIT,DNA- pkcs (EC 2.7.11.1)	protein	3704	61% helix, 2% strand	P78527

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	872	0.86	0.88	111	empty
2	1024	0.83	0.84	111	empty
3	1165	0.79	0.81	120	empty
4	352	0.78	0.88	44	empty
5	713	0.78	0.82	83	empty

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P78527
Elsewhere: RCSB PDB 6ZH2 · PDBe 6ZH2 · UniProt P78527

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