Research workbench
Glic pentameric ligand-gated ion channel, pH 7
Analyse Glic pentameric ligand-gated ion channel, pH 7 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ZGD
- Type
- protein
- Length
- 1,440 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proton-gated ion channel
- UniProt
- Q7NDN8
- Pockets
- 14 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 35% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Proton-gated ion channel | protein | 288 | 35% helix, 28% strand | Q7NDN8 |
Pockets
14 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1064 | 0.85 | 0.86 | 120 | empty |
| 2 | 1025 | 0.85 | 0.86 | 121 | empty |
| 3 | 1039 | 0.84 | 0.85 | 126 | empty |
| 4 | 692 | 0.84 | 0.87 | 110 | empty |
| 5 | 1158 | 0.83 | 0.84 | 120 | empty |
Interfaces
5 interfaces between chains.
- A–E · 1740 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 1731 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 1731 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 1728 Ų buried · 6 hydrogen bonds · protein-protein
- D–E · 1725 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7NDN8
- Elsewhere: RCSB PDB 6ZGD · PDBe 6ZGD · UniProt Q7NDN8
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