Research workbench
Human insulin in complex with the analytical antibody oxi-005 Fab
Analyse Human insulin in complex with the analytical antibody oxi-005 Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6Z7Y
- Type
- protein
- Length
- 943 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Oxi-005 Fab light chain; Oxi-005 Fab heavy chain; Insulin
- UniProt
- P01308
- Pockets
- 13 · best druggability 0.52
Structure
x-ray diffraction · 7 distinct chains · 9% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Oxi-005 Fab light chain | protein | 213 | 5% helix, 51% strand | — |
| B | Oxi-005 Fab heavy chain | protein | 211 | 7% helix, 52% strand | — |
| C | Oxi-005 Fab light chain | protein | 211 | 5% helix, 54% strand | — |
| D | Oxi-005 Fab heavy chain | protein | 209 | 9% helix, 53% strand | — |
| E, G | Insulin | protein | 21 | 48% helix, 5% strand | P01308 |
| F | Insulin | protein | 29 | 31% helix, 3% strand | P01308 |
| H | Insulin | protein | 28 | 32% helix, 4% strand | P01308 |
Pockets
13 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 112 | 0.52 | 0.82 | 21 | empty |
| 2 | 76 | 0.52 | 0.85 | 24 | empty |
| 3 | 146 | 0.46 | 0.77 | 27 | empty |
| 4 | 155 | 0.45 | 0.76 | 27 | empty |
| 5 | 115 | 0.38 | 0.74 | 17 | empty |
Interfaces
13 interfaces between chains.
- A–B · 1914 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 1751 Ų buried · 16 hydrogen bonds · protein-protein
- E–F · 745 Ų buried · 11 hydrogen bonds · protein-protein
- G–H · 726 Ų buried · 11 hydrogen bonds · protein-protein
- D–F · 410 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 disulfide (disulfide).
Compared structures
- 6Z7Y · Human insulin in complex with the analytical antibody OXI-005 Fab · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 6Z7Y · PDBe 6Z7Y · UniProt P01308
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