Research workbench
Human insulin in complex with the analytical antibody hui-018 Fab
Analyse Human insulin in complex with the analytical antibody hui-018 Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6Z7W
- Type
- protein
- Length
- 1,902 residues
- Chains
- 16
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mab 6H10 light chain; Hui-018 Fab heavy chain; Insulin
- UniProt
- P01308
- Pockets
- 18 · best druggability 0.64
Structure
x-ray diffraction · 11 distinct chains · 9% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E, G | Mab 6H10 light chain | protein | 214 | 7% helix, 50% strand | — |
| B | Hui-018 Fab heavy chain | protein | 220 | 4% helix, 51% strand | — |
| C | Mab 6H10 light chain | protein | 213 | 5% helix, 49% strand | — |
| D | Hui-018 Fab heavy chain | protein | 213 | 4% helix, 53% strand | — |
| F | Hui-018 Fab heavy chain | protein | 216 | 6% helix, 53% strand | — |
| H | Hui-018 Fab heavy chain | protein | 219 | 5% helix, 52% strand | — |
| I | Insulin | protein | 16 | 44% helix, 0% strand | P01308 |
| J, L | Insulin | protein | 24 | 58% helix, 13% strand | P01308 |
| K, M, O | Insulin | protein | 21 | 48% helix, 5% strand | P01308 |
| N | Insulin | protein | 26 | 58% helix, 12% strand | P01308 |
| P | Insulin | protein | 26 | 58% helix, 12% strand | P01308 |
Pockets
18 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 705 | 0.64 | 0.74 | 92 | empty |
| 2 | 371 | 0.55 | 0.74 | 55 | empty |
| 3 | 330 | 0.54 | 0.74 | 52 | empty |
| 4 | 289 | 0.52 | 0.74 | 46 | empty |
| 5 | 286 | 0.52 | 0.74 | 42 | empty |
Interfaces
35 interfaces between chains.
- E–F · 1887 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1877 Ų buried · 14 hydrogen bonds · protein-protein
- G–H · 1871 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 1683 Ų buried · 14 hydrogen bonds · protein-protein
- O–P · 632 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 29 disulfide (disulfide).
Compared structures
- 6Z7W · Human insulin in complex with the analytical antibody HUI-018 Fab · the same entry in another collection · chain P against P, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 6Z7W · PDBe 6Z7W · UniProt P01308
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