Galectin-8 N-terminal domain in complex with a sulfatide mimicking a sphingolipid

Structure

x-ray diffraction · 1 distinct chain · 4% helix, 57% strand (DSSP).

Ligands and binding sites

• L4L · [(2~{R},3~{R},4~{S},5~{S},6~{R})-2-[(2~{S})-2-acetamido-3-oxidanylidene-pent-4-enoxy]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-4-yl] hydrogen sulfate · ligand · chains A
• ACT · Acetate ion · additive · 6 copies · chains A
• PGE · Triethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Compared structures

• 6Z6Y · Galectin-8 N-terminal domain in complex with a sulfatide mimicking a sphingolipid · the same entry in another collection · chain A against A, TM-score 1.00
• O00214 · AlphaFold monomer V2.0 prediction for galectin-8 (O00214) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O00214
• Elsewhere: RCSB PDB 6Z6Y · PDBe 6Z6Y · UniProt O00214