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Crystal structure of adhibin analogue-bound myosin-2

Analyse Crystal structure of adhibin analogue-bound myosin-2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6Z2S
Type: protein
Length: 748 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myosin-2 heavy chain
UniProt: P08799
Ligands: Q5Q, AD9, MG
Pockets: 7 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Myosin-2 heavy chain	protein	748	44% helix, 16% strand	P08799

Ligands and binding sites

Q5Q · 3,6-dibromo-1-(hydroxymethyl)carbazole · ligand · chains A
AD9 · Adp metavanadate · ligand · chains A
MG · Magnesium ion · metal · chains A
GOL · Glycerol · additive · 5 copies · chains A
ACT · Acetate ion · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	914	0.77	0.79	70	Q5Q, GOL, ACT
2	711	0.72	0.78	62	empty
3	477	0.67	0.79	54	MG, AD9
4	89	0.46	0.81	23	empty
5	70	0.40	0.79	14	empty

Compared structures

6Z2S · Crystal structure of adhibin analogue-bound myosin-2 · the same entry in another collection · chain A against A, TM-score 1.00
P08799 · AlphaFold monomer V2.0 prediction for myosin-2 heavy chain (P08799) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08799
Elsewhere: RCSB PDB 6Z2S · PDBe 6Z2S · UniProt P08799

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