Research workbench
Crystal structure of a DNA repair complex ASCC3-ASCC2
Analyse Crystal structure of a DNA repair complex ASCC3-ASCC2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6YXQ
- Type
- protein
- Length
- 584 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1…
- EC
- 3.6.4.12
- UniProt
- Q8N3C0, Q9H1I8
- Pockets
- 9 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) | protein | 188 | 62% helix, 0% strand | Q8N3C0 |
| B | Activating signal cointegrator 1 complex subunit 2 | protein | 396 | 69% helix, 3% strand | Q9H1I8 |
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 752 | 0.68 | 0.75 | 54 | empty |
| 2 | 232 | 0.60 | 0.80 | 22 | empty |
| 3 | 98 | 0.44 | 0.79 | 17 | empty |
| 4 | 51 | 0.44 | 0.84 | 13 | empty |
| 5 | 114 | 0.40 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 3477 Ų buried · 38 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 6YXQ · Crystal structure of a DNA repair complex ASCC3-ASCC2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H1I8 · AlphaFold monomer V2.0 prediction for activating signal cointegrator 1 complex subunit 2… · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q8N3C0 · AlphaFold monomer V2.0 prediction for activating signal cointegrator 1 complex subunit 3… · a predicted model of the same protein · chain A against A, TM-score 0.58
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N3C0
- Every structure of UniProt Q9H1I8
- Elsewhere: RCSB PDB 6YXQ · PDBe 6YXQ · UniProt Q8N3C0 · UniProt Q9H1I8
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