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Small-molecule stabilizer of 14-3-3 and the carbohydrate response element binding protein (chrebp) protein-protein interaction

Analyse Small-molecule stabilizer of 14-3-3 and the carbohydrate response element… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6YGJ
Type: protein
Length: 495 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P31946, Q9NP71
Ligands: OQE

Structure

x-ray diffraction · 3 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	227	—	P31946
B, I	—	protein	20	—	Q9NP71
F	—	protein	228	—	P31946

Ligands and binding sites

OQE · [2-[2-oxidanylidene-2-(2-phenylethylamino) ethoxy]phenyl]phosphonic acid · ligand · 2 copies · chains A, B, F, I

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6YGJ · small-molecule stabilizer of 14-3-3 and the Carbohydrate Response Element Binding Protein… · the same entry in another collection · chain A against A, TM-score 1.00
P31946 · AlphaFold monomer V2.0 prediction for 14-3-3 protein BETA/ALPHA (P31946) · a predicted model of the same protein · chain A against A, TM-score 0.99
Q9NP71 · AlphaFold monomer V2.0 prediction for carbohydrate-responsive element-binding protein… · a predicted model of the same protein · chain B against A, TM-score 0.53

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31946
Every structure of UniProt Q9NP71
Elsewhere: RCSB PDB 6YGJ · PDBe 6YGJ · UniProt P31946 · UniProt Q9NP71

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