UniProt P31946
14-3-3 protein beta/alpha (P31946)
14-3-3 protein beta/alpha (UniProt P31946): 27 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P31946
- Protein
- 14-3-3 protein beta/alpha
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 26 · 5 records with a druggable one
Structures
28 records of P31946 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2BQ0 | 14-3-3 Protein Beta (Human) | x-ray diffraction | A, B | — | — |
| 2BQ0 | 14-3-3 protein beta (human) | x-ray diffraction | A, B | — | — |
| 2C23 | 14-3-3 Protein Beta (Human) in complex with exoenzyme S peptide | x-ray diffraction | A | — | — |
| 2C23 | 14-3-3 protein beta (human) in complex with exoenzyme S peptide | x-ray diffraction | A | — | — |
| 4DNK | Crystal structure of a tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta… | x-ray diffraction | A, B | — | — |
| 4DNK | Crystal structure of a tyrosine 3-MONOOXYGENASE/TRYPTOPHAN 5- monooxygenase activation protein… | x-ray diffraction | A, B | — | — |
| 5N10 | Cucurbit[8]uril and 14-3-3 based binary bivalent supramolecular-protein assembly platform | x-ray diffraction | A, B | C8L | 5 (best 0.55) |
| 5N10 | CUCURBIT[8]URIL and 14-3-3 based binary bivalent supramolecular- protein assembly platform | x-ray diffraction | A, B | C8L | — |
| 6A5Q | Structure of 14-3-3 beta in complex with TFEB 14-3-3 binding motif | x-ray diffraction | B, A, C | — | — |
| 6A5Q | Structure of 14-3-3 beta in complex with tfeb 14-3-3 binding motif | x-ray diffraction | B, A, C | — | — |
| 6BYK | Structure of 14-3-3 beta/alpha bound to O-ClcNAc peptide | x-ray diffraction | A, B, C, D | NAG | — |
| 6BYK | Structure of 14-3-3 BETA/ALPHA bound to O-clcnac peptide | x-ray diffraction | A, B, C, D | NAG | — |
| 6GN0 | Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, tetrameric… | x-ray diffraction | A, B, C, D | — | — |
| 6GN0 | Exoenzyme S from pseudomonas aeruginosa in complex with human 14-3-3 protein beta, tetrameric… | x-ray diffraction | A, B, C, D | — | — |
| 6GN8 | Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal… | x-ray diffraction | A, B | — | — |
| 6GN8 | Exoenzyme S from pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal… | x-ray diffraction | A, B | — | — |
| 6GNJ | Exoenzyme S from pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal… | x-ray diffraction | A, B | — | — |
| 6GNK | Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal… | x-ray diffraction | A, B | — | — |
| 6GNK | Exoenzyme S from pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal… | x-ray diffraction | A, B | — | — |
| 6GNN | Exoenzyme T from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, tetrameric… | x-ray diffraction | A | — | — |
| 6GNN | Exoenzyme T from pseudomonas aeruginosa in complex with human 14-3-3 protein beta, tetrameric… | x-ray diffraction | A | — | — |
| 6HEP | Crystal structure of human 14-3-3 beta in complex with CFTR R-domain peptide pS753-pS768 | x-ray diffraction | A, B, C, D | ETE | 11 (best 0.70) |
| 6HEP | Crystal structure of human 14-3-3 beta in complex with cftr R-domain peptide PS753-PS768 | x-ray diffraction | A, B, C, D | ETE | — |
| 6YGJ | small-molecule stabilizer of 14-3-3 and the Carbohydrate Response Element Binding Protein (ChREBP)… | x-ray diffraction | A, F | OQE | 5 (best 0.69) |
| 6YGJ | Small-molecule stabilizer of 14-3-3 and the carbohydrate response element binding protein (chrebp)… | x-ray diffraction | A, F | OQE | — |
| 8DP5 | Structure of the PEAK3/14-3-3 complex | electron microscopy | C | — | 3 (best 0.61) |
| 8EQH | The crystal structure of 14-3-3 Beta containing 3-nitrotyrosine at position Y213 | x-ray diffraction | B, A | — | 2 (best 0.53) |
| P31946 | AlphaFold monomer V2.0 prediction for 14-3-3 protein BETA/ALPHA (P31946) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6BYK chain C against the predicted model P31946: TM-score 0.99, RMSD 0.60 Å
- 6BYK chain C against the predicted model P31946: TM-score 0.99, RMSD 0.60 Å
- 6YGJ chain A against the predicted model P31946: TM-score 0.99, RMSD 0.62 Å
- 6YGJ chain A against the predicted model P31946: TM-score 0.99, RMSD 0.62 Å
- 6YGJ chain F against the predicted model P31946: TM-score 0.99, RMSD 0.65 Å
- 6YGJ chain F against the predicted model P31946: TM-score 0.99, RMSD 0.65 Å
- 6GN8 chain B against the predicted model P31946: TM-score 0.99, RMSD 0.65 Å
- 6GN8 chain B against the predicted model P31946: TM-score 0.99, RMSD 0.65 Å
- 6A5Q chain A against the predicted model P31946: TM-score 0.99, RMSD 0.69 Å
- 6A5Q chain A against the predicted model P31946: TM-score 0.99, RMSD 0.69 Å
Elsewhere
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