Crystal structure of the BCL6 btb domain in complex with the NCOR1 BBD2 peptide

Structure

x-ray diffraction · 2 distinct chains · 49% helix, 17% strand (DSSP).

Ligands and binding sites

• NA · Sodium ion · metal · 7 copies · chains A
• CL · Chloride ion · ion · 2 copies · chains A
• TFA · trifluoroacetic acid · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 403 Ų buried · 12 hydrogen bonds · protein-protein

Compared structures

• 6XZZ · Crystal structure of the BCL6 BTB domain in complex with the NCoR1 BBD2 peptide · the same entry in another collection · chain A against A, TM-score 1.00
• O75376 · AlphaFold monomer V2.0 prediction for nuclear receptor corepressor 1 (O75376) · a predicted model of the same protein · chain B against A, TM-score 0.43
• P41182 · AlphaFold monomer V2.0 prediction for B-cell lymphoma 6 protein (P41182) · a predicted model of the same protein · chain A against A, TM-score 0.31

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P41182
• Every structure of UniProt O75376
• Elsewhere: RCSB PDB 6XZZ · PDBe 6XZZ · UniProt P41182 · UniProt O75376