UniProt O75376
Nuclear receptor corepressor 1 (O75376)
Nuclear receptor corepressor 1 (UniProt O75376): 22 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O75376
- Protein
- Nuclear receptor corepressor 1
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 9 · 2 records with a druggable one
Structures
23 records of O75376 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2EQR | Solution structure of the first SANT domain from human nuclear receptor corepressor 1 | solution nmr | A | — | — |
| 2EQR | Solution structure of the first sant domain from human nuclear receptor corepressor 1 | solution nmr | A | — | — |
| 3H52 | Crystal structure of the antagonist form of human glucocorticoid receptor | x-ray diffraction | N, M | — | — |
| 3H52 | Crystal structure of the antagonist form of human glucocorticoid receptor | x-ray diffraction | N, M | — | — |
| 3KMZ | Crystal structure of RARalpha ligand binding domain in complex with the inverse agonist BMS493 and… | x-ray diffraction | C, D | — | — |
| 3KMZ | Crystal structure of raralpha ligand binding domain in complex with the inverse agonist BMS493 and… | x-ray diffraction | C, D | — | — |
| 3N00 | Crystal Structure of a deletion mutant of human Reverba ligand binding domain bound with an NCoR… | x-ray diffraction | B | — | — |
| 3N00 | Crystal structure of a deletion mutant of human reverba ligand binding domain bound with an ncor… | x-ray diffraction | B | — | — |
| 4MDD | Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals… | x-ray diffraction | C, D | — | — |
| 4MDD | Crystal structure of the glucocorticoid receptor bound to a non- steroidal antagonist reveals… | x-ray diffraction | C, D | — | — |
| 4WVD | Identification of a novel FXR ligand that regulates metabolism | x-ray diffraction | C, D | — | — |
| 4WVD | Identification of a novel fxr ligand that regulates metabolism | x-ray diffraction | C, D | — | — |
| 6WMQ | Crystal structure of human rev-erbbeta ligand binding domain co-bound to heme and ncor ID1 peptide | x-ray diffraction | E, F | HEM | — |
| 6XXS | Crystal structure of an NCOR1BBD2-BCL6BTB chimera in complex with the NCOR1 BBD1 corepressor… | x-ray diffraction | C, D, G, H | — | — |
| 6XYX | Crystal structure of the BCL6 btb domain in complex with the NCOR1 bbd corepressor peptide | x-ray diffraction | D, C | — | — |
| 6XZZ | Crystal structure of the BCL6 btb domain in complex with the NCOR1 BBD2 peptide | x-ray diffraction | B | — | — |
| 6Y17 | Crystal structure of an NCOR1BBD2-BCL6BTB chimera in complex with NEBULINSH3-NCOR1BBD1 | x-ray diffraction | A, B, C, D | NA | — |
| 6ZBU | Crystal structure of an NCOR1BBD2-BCL6BTB chimera in complex with the NCOR1 BBD1 corepressor peptide | x-ray diffraction | A, B, C, D, E, F, G, I, J, K, L, H | SO4 | — |
| 8AS9 | Crystal structure of the talin-KANK1 complex | x-ray diffraction | D | SO4 | 1 (best 0.50) |
| 8DKN | PPARg bound to T0070907 and Co-R peptide | x-ray diffraction | C | SO4 | 1 (best 0.32) |
| 8FKD | Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and inverse… | x-ray diffraction | D | — | 1 (best 0.60) |
| 8FKE | Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and inverse… | x-ray diffraction | D | — | — |
| O75376 | AlphaFold monomer V2.0 prediction for nuclear receptor corepressor 1 (O75376) | predicted | A | — | 6 (best 0.43) |
Ligands
Experiment against prediction
- 8FKD chain D against the predicted model O75376: TM-score 0.84, RMSD 0.24 Å
- 8FKE chain D against the predicted model O75376: TM-score 0.80, RMSD 0.30 Å
- 4MDD chain D against the predicted model O75376: TM-score 0.77, RMSD 0.32 Å
- 4MDD chain D against the predicted model O75376: TM-score 0.77, RMSD 0.32 Å
- 4MDD chain C against the predicted model O75376: TM-score 0.70, RMSD 0.36 Å
- 4MDD chain C against the predicted model O75376: TM-score 0.70, RMSD 0.36 Å
- 2EQR chain A against the predicted model O75376: TM-score 0.69, RMSD 2.07 Å
- 2EQR chain A against the predicted model O75376: TM-score 0.69, RMSD 2.07 Å
- 3H52 chain M against the predicted model O75376: TM-score 0.68, RMSD 0.33 Å
- 3H52 chain M against the predicted model O75376: TM-score 0.68, RMSD 0.33 Å
Elsewhere
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