Research workbench
Multiple system atrophy type II-1 alpha-synuclein filament
Analyse Multiple system atrophy type II-1 alpha-synuclein filament in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6XYP
- Type
- protein
- Length
- 725 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-synuclein
- UniProt
- P37840
- Pockets
- 8 · best druggability 0.73
Structure
electron microscopy · 2 distinct chains · 0% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G, I | Alpha-synuclein | protein | 81 | 0% helix, 51% strand | P37840 |
| B, D, F, H, J | Alpha-synuclein | protein | 64 | 0% helix, 47% strand | P37840 |
Pockets
8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 479 | 0.73 | 0.83 | 47 | empty |
| 2 | 312 | 0.72 | 0.86 | 43 | empty |
| 3 | 124 | 0.64 | 0.88 | 30 | empty |
| 4 | 264 | 0.63 | 0.81 | 33 | empty |
| 5 | 160 | 0.61 | 0.85 | 34 | empty |
Interfaces
29 interfaces between chains.
- G–I · 3064 Ų buried · 90 hydrogen bonds · protein-protein
- C–E · 3052 Ų buried · 92 hydrogen bonds · protein-protein
- A–I · 3050 Ų buried · 92 hydrogen bonds · protein-protein
- A–E · 3046 Ų buried · 88 hydrogen bonds · protein-protein
- H–J · 2490 Ų buried · 78 hydrogen bonds · protein-protein
Compared structures
- 6XYP · Multiple system atrophy Type II-1 alpha-synuclein filament · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37840
- Elsewhere: RCSB PDB 6XYP · PDBe 6XYP · UniProt P37840
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