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Structural insight into sheep-pox virus mediated inhibition of apoptosis

Analyse Structural insight into sheep-pox virus mediated inhibition of apoptosis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XY6
Type: protein
Length: 1,261 residues
Chains: 16
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Anti-apoptotic membrane protein; Apoptosis regulator bax
UniProt: A0A3F2YKH3, Q07812
Pockets: 9 · best druggability 0.79

Structure

x-ray diffraction · 11 distinct chains · 80% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, G	Anti-apoptotic membrane protein	protein	135	78% helix, 0% strand	A0A3F2YKH3
B	Apoptosis regulator bax	protein	23	87% helix, 0% strand	Q07812
C	Anti-apoptotic membrane protein	protein	138	79% helix, 0% strand	A0A3F2YKH3
D	Apoptosis regulator bax	protein	23	91% helix, 0% strand	Q07812
E, I, M	Anti-apoptotic membrane protein	protein	133	78% helix, 0% strand	A0A3F2YKH3
F, J, L	Apoptosis regulator bax	protein	25	88% helix, 0% strand	Q07812
H	Apoptosis regulator bax	protein	24	92% helix, 0% strand	Q07812
K	Anti-apoptotic membrane protein	protein	134	78% helix, 0% strand	A0A3F2YKH3
N	Apoptosis regulator bax	protein	22	91% helix, 0% strand	Q07812
O	Anti-apoptotic membrane protein	protein	132	79% helix, 0% strand	A0A3F2YKH3
P	Apoptosis regulator bax	protein	21	90% helix, 0% strand	Q07812

Pockets

9 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	464	0.79	0.87	33	empty
2	408	0.78	0.87	32	empty
3	383	0.78	0.88	33	empty
4	451	0.70	0.81	54	empty
5	311	0.70	0.84	36	empty

Interfaces

23 interfaces between chains.

G–H · 967 Å² buried · 12 hydrogen bonds · protein-protein
C–D · 954 Å² buried · 7 hydrogen bonds · protein-protein
K–L · 944 Å² buried · 15 hydrogen bonds · protein-protein
A–B · 940 Å² buried · 8 hydrogen bonds · protein-protein
I–J · 934 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

6XY6 · Structural insight into sheep-pox virus mediated inhibition of apoptosis · the same entry in another collection · chain G against G, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A3F2YKH3
Every structure of UniProt Q07812
Elsewhere: RCSB PDB 6XY6 · PDBe 6XY6 · UniProt A0A3F2YKH3 · UniProt Q07812

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