Research workbench

Arabidopsis thaliana casein kinase 2 (CK2) alpha-1 crystal form II

Analyse Arabidopsis thaliana casein kinase 2 (CK2) alpha-1 crystal form II in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XX8
Type: protein
Length: 660 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Casein kinase II subunit alpha-1
EC: 2.7.11.1
UniProt: Q08467
Pockets: 3 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Casein kinase II subunit alpha-1 (EC 2.7.11.1)	protein	326	42% helix, 16% strand	Q08467
B	Casein kinase II subunit alpha-1 (EC 2.7.11.1)	protein	334	44% helix, 15% strand	Q08467

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	970	0.83	0.85	111	empty
2	163	0.64	0.85	29	empty
3	80	0.43	0.80	19	empty

Interfaces

1 interface between chains.

A–B · 472 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

6XX8 · Arabidopsis thaliana Casein Kinase 2 (CK2) alpha-1 crystal form II · the same entry in another collection · chain A against A, TM-score 1.00
Q08467 · AlphaFold monomer V2.0 prediction for casein kinase II subunit alpha-1 (Q08467) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q08467
Elsewhere: RCSB PDB 6XX8 · PDBe 6XX8 · UniProt Q08467

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