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Crystal structure of the C-src SH3 domain H122R-Q128E mutant in complex with NI(II) at pH 7.5 co-crystallized with methyl beta- cyclodextrin

Analyse Crystal structure of the C-src SH3 domain H122R-Q128E mutant in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XX4
Type: protein
Length: 55 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proto-oncogene tyrosine-protein kinase src
EC: 2.7.10.2
UniProt: P00523
Ligands: ZB2, ZB1, ZB3, ZB0, GLC, NI

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Proto-oncogene tyrosine-protein kinase src (EC 2.7.10.2)	protein	55	5% helix, 45% strand	P00523

Ligands and binding sites

ZB2 · 2-O-methyl-alpha-D-glucopyranose · ligand · 2 copies
ZB1 · 3-O-methyl-alpha-D-glucopyranose · ligand
ZB3 · 2,6-di-O-methyl-alpha-D-glucopyranose · ligand
ZB0 · 2,3-di-O-methyl-alpha-D-glucopyranose · ligand
GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
NI · Nickel (II) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6XX4 · Crystal structure of the c-Src SH3 domain H122R-Q128E mutant in complex with Ni(II) at pH… · the same entry in another collection · chain A against A, TM-score 1.00

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Every structure of UniProt P00523
Elsewhere: RCSB PDB 6XX4 · PDBe 6XX4 · UniProt P00523

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